hyperinsulinemia insulin receptor dysfunction?
Type 1 Diabetes is associated with an autoimmune disease that destroys the beta islet cells of the pancreas and thus effects the loss of insulin production. In contrast Type 2 Diabetes is associated with insulin resistance and hyperinsulinemia. This suggests the following:
1. The insulin receptors are mutated.
2. Post insulin receptor molecules are inactive or mutated.
3. There is an increase in insulin/insulin receptor endocytosis that is greater than that observed in normal tissue.
4. One or more of the above.
I’ve scoured my lecture notes and can’t find anything on this. Can you help?
The insulin elevation is being driven by a constant slightly higher than normal blood sugar. Most likely secondary to the insulin resistance.
There is no known cure, although, metformin does help alot. Metformin does have potential side effects and it is recommended that your kidney function be checked while being on metformin regularly.
I have found an Herbal product called "Glucose Factors" which has helped bring down HgA1C levels and C-peptide levels (cheap insulin level check) in my patients.
Depending on your health care philosophy, you have two choices here to try.
Exercise 30 min. 3-4- times a week and weight loss if needed are important as well.
Hope this helps.
Posted in Diabetes Type 2 Insulin Resistance
hyperinsulinemia insulin receptor dysfunction means that due to defect in insulin receptor the blood glucose level is not going down which in turn constantly leading to stimulation of pancreas to release insulin causing hyperinsulinemia
References :
All are correct.
The hyperinsulinemia seen here has been observed for at least 30 years, but still is very rarely treated. In Western type medical practice, a ‘pre-illness’ (eg. pre DM type 2) should be at least started on a Biguanide+diet, (like it has been in Europe for the past 25 -30 years)…Actually, metformin is available, there, over the counter, as an appetite supressant.Alas, it’s still not well enough integrated into our medical establishment that the major cause of ‘being hungry all the time’ is high circulating serum insulin levels.
References :
The insulin elevation is being driven by a constant slightly higher than normal blood sugar. Most likely secondary to the insulin resistance.
There is no known cure, although, metformin does help alot. Metformin does have potential side effects and it is recommended that your kidney function be checked while being on metformin regularly.
I have found an Herbal product called "Glucose Factors" which has helped bring down HgA1C levels and C-peptide levels (cheap insulin level check) in my patients.
Depending on your health care philosophy, you have two choices here to try.
Exercise 30 min. 3-4- times a week and weight loss if needed are important as well.
Hope this helps.
References :
http://alternativehealthedge.com
twenty-seven years in internal medicine.